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T6540 |
Ibuprofen Lysine
|
Neoprofen |
COX
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|
Ibuprofen Lysine (Neoprofen) is a non-steroidal anti-inflammatory drug. |
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T1394 |
Ibuprofen
|
Brufen,(±)-Ibuprofe,Motrin,Advil |
COX
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|
Ibuprofen (Advil) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resu... |
|
T35343 |
MTI-31
|
MTI-31,LXI-15029 |
mTOR
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MTI-31 (LXI-15029) is a potent, orally active and highly selective inhibitor of mTORC1 and mTORC2. MTI-31 is selective for mTOR (Kd: 0.20 nM) versus PIK3CA, PIK3CB and PIK3G with >5,000 fold selectivity in mTOR binding a... |
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T12516 |
Polyinosinic-polycytidylic acid sodium
|
Poly(I:C) sodium |
Apoptosis
,
Others
,
TLR
|
|
Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MD... |
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T3633 |
Crenigacestat
|
LY3039478 |
Gamma-secretase
|
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Crenigacestat (LY3039478) is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most of the tumor cell lines tested. Crenigacestat effectively inhibits mutant Notch receptor activity. In a xenograft tumor mo... |
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T31825 |
Fluoromisonidazole
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|
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Fluoromisonidazole, a Radiation-Sensitizing Agent, can be used for imaging tumor hypoxia: imaging the microenvironment for personalized cancer therapy. |
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T22725 |
DiMNF
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Others
|
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DiMNF is a selective aryl hydrocarbon receptor (AHR) modulator.
It also suppresses the expression of CD55 and CD46 induced by IL-1β in an inflammatory tumor cell microenvironment. |
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T69648 |
Inupadenant HCl
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|
|
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Inupadenant, also known as EOS-850, is a highly selective small molecule antagonist of the adenosine A2a receptor, in the adenosine triphosphate adenosine pathway, a key driver of immunosuppression in the tumor microenv... |
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T78521 |
Mc-Alanyl-Alanyl-Asparagine-PAB-MMAE
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|
Others
|
|
Compound S6, Mc-Alanyl-Alanyl-Asparagine-PAB-MMAE, is a potent anticancer agent specifically activated by the tumor microenvironment; it demonstrates efficacy in suppressing tumor growth in mice[1]. |
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T78250 |
Selicrelumab
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Selicrelumab, an agonist CD40 antibody, modifies the tumor microenvironment and is utilized in pancreatic cancer research and neoadjuvant studies [1]. |
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T74507 |
IDO1-IN-20
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|
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IDO1-IN-20 is an enzyme that catalyzes the oxidative metabolism of tryptophan. It can immunosuppress tumors in the tumor microenvironment. |
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T74975 |
Zn-DPA-maytansinoid conjugate 1
|
|
|
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Zn-DPA-maytansinoid conjugate 1, a small molecule-based immune checkpoint-targeting maytansinoid conjugate, effectively induces sustained tumor growth regression and transforms the tumor microenvironment (TME) into an "i... |
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T82268 |
Gotistobart
|
BNT 316,ONC-392 |
|
|
Gotistobart (ONC-392) is a humanized anti-CTLA-4 antibody that enhances immunotherapy by selectively depleting regulatory T cells (Treg) within the tumor microenvironment [1]. |
|
T13538 |
AlbA-DCA
|
|
ROS
|
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AlbA-DCA is a conjugate formed by the attachment of Albiziabioside A to a dichloroacetate acid subunit. It can induce a marked increase in intracellular ROS and alleviate the accumulation of lactic acid in the tumor micr... |
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T10713 |
CCR4 antagonist 2
|
|
Calcium Channel
|
|
CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the n... |
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T40099 |
ALV2
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|
|
|
ALV2 is a potent and selective Helios degrader compound that binds to the CRBN protein, exhibiting an IC50 value of 0.57 μM. Helios, a zinc-finger transcription factor, plays a crucial role in preserving a stable T reg c... |
|
T79199 |
F-CRI1
|
|
STING
|
|
F-CRI1, a potent STING agonist with a dissociation constant (K d) of 40.62 nM, is an 18F-labeled radioactive probe employed for visualizing STING in the tumor microenvironment [1]. |
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T76983 |
Tengonermin
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|
|
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Tengonermin (ARENEGYR), a vascular-targeting compound, comprises human Tumour Necrosis Factor-α (TNF-α) conjugated with the CNGRCG peptide. It enhances intratumoral chemotherapy delivery and T-cell infiltration by alteri... |
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T35587 |
Ganglioside GD1a mixture (sodium salt)
|
Ganglioside B1 |
|
|
Ganglioside GD1a is a sialic acid-containing glycosphingolipid found in brain, erythrocytes, bone marrow, testis, spleen, and liver. [1] It can be shed from the surface of tumor cells into the microenvironment where it i... |
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T77090 |
Mitazalimab
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|
|
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Mitazalimab (ADC-1013; JNJ-64457107) is an FcγR-dependent CD40 agonist that exhibits directed activity against tumors. By activating antigen-presenting cells, such as dendritic cells (DC), it triggers the initiation of t... |
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T36900 |
PD-1/PD-L1-IN-NP19
|
PD-1/PD-L1-IN-NP19 |
PD-1/PD-L1
|
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PD-1/PD-L1-IN-NP19, a PD-1/PD-L1 inhibitor, exhibits an IC50 of 12.5 nM against the human PD-1/PD-L1 interaction, potentially activating the tumor immune microenvironment and contributing to its antitumor effects[1]. |
|
T77189 |
Sudubrilimab
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Sudubrilimab (HS636), an Ig G1-kappa monoclonal antibody targeting PDL1, is engineered with a TGF-β1 receptor II ectodomain (TGFBR2-ECD) fused to its C-terminus. This design enables Sudubrilimab to simultaneously inhibit... |
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T72668 |
PD-1/PD-L1-IN-26
|
|
PD-1/PD-L1
|
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PD-1/PD-L1-IN-26 (Compound II-14) is a potent PD-1/PD-L1 inhibitor, demonstrating an IC50 of 0.0380 μM. It enhances the immune microenvironment by facilitating CD4+ T cell infiltration into tumor tissues, indicating pote... |
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T79205 |
PD-1/PD-L1-IN-34
|
|
PD-1/PD-L1
|
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PD-1/PD-L1-IN-34 (Compound (1S,2S)-A25) effectively inhibits the PD-1/PD-L1 interaction (IC 50 = 0.029 μM) and demonstrates selective binding affinity to PD-L1 (K D = 0.1554 μM), resulting in the activation of the immune... |
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T76255 |
Certepetide
|
|
|
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Certepetide (CEND-1), also known as iRGD, is a bifunctional cyclic peptide that enhances tumor penetration. By interacting with alphav-integrins through its RGD motif and activating NRP-1, it transforms the solid tumor m... |
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T74052 |
Polyinosinic-polycytidylic acid potassium
|
|
|
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Polyinosinic-polycytidylic acid potassium (Poly(I:C) potassium), a synthetic double-stranded RNA analog, serves as an agonist for toll-like receptor 3 (TLR3) and retinoic acid-inducible gene I (RIG-I)-like receptors (RIG... |
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T83877 |
2-(cyclohexylmethyl)-Plumbagin
|
|
|
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2-(Cyclohexylmethyl)-Plumbagin, a naphthoquinone derivative, exhibits selective cytotoxicity towards PANC-1 human pancreatic cancer cells under nutrient-deprived conditions—a situation akin to the pancreatic cancer tumor... |
